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86-4017-62Phospho-BRCA1S988 Polyclonal Antibody 120uL E-AB-68129

86-4017-62Phospho-BRCA1S988 Polyclonal Antibody 120uL E-AB-68129

品番: Y3mM0qzK2yvXFrL

冷凍 【輸入試薬に関するお問合せ】 アズワン株式会社 輸入試薬グループ TEL:06-6447-8641 FAX:06-6447-8642 E-mail: 特徴 背景:This gene encodes a nuclear phosphoprotein that plays...
63,000円  22,450円割引: 64%OFF

アイテム説明

  • 冷凍

  • 【輸入試薬に関するお問合せ】
  • アズワン株式会社 輸入試薬グループ
  • TEL:06-6447-8641
  • FAX:06-6447-8642
  • E-mail:

特徴

  • 背景:This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified.

仕様

  • 抗体タイプ:Phosphorylated antibody
  • アプリケーション:IF
  • 交差性:Human
  • 宿主:Rabbit
  • アイソタイプ:IgG
  • 抗原:A synthetic phosphorylated peptide around S988 of human BRCA1 (NP_009225.1).
  • 緩衝液:PBS with 0.02% sodium azide, 50% glycerol, pH7.3
  • 精製方法:Affinity purification
  • 希釈倍率:IF 1:50-1:200
  • 標識:Unconjugated
  • メーカーマニュアル:https://file.elabscience.com/viewpdf-391381-Elabscience-E-AB-68129.pdf
  • サイズ:120uL
  • この商品は法規制を確認しておりません。(法規制によって販売できない場合もございます)